Bioinformatics: Construction of a centralized database with brain imaging, genetic, psychometric and behavioural data, and associated database related tools (Part A). For this, we will collaborate with NordicNeuroLab (NNL) and Scito, an SME with experience in neuro-imaging data transfer and data analysis through web systems (www.scito.com). NNL will be responsible for formatting the data and perform a first automatic quality check of the data with the help of other partners (CEA). Scito will develop a product to perform secure transfer and of all imaging and psychophysic data (interfacing with WP4) and handle a three level anonymisation procedure. Specific consulting will be given by Tembit that specialize in anonymisation procedure for large multi centric project. The database will be constructed by the bioinformatic team at CEA, which will benefit from the expertise of Pertimm, an SME developing innovative database solutions searching to expand their current applications. Its experience in large database systems will be invaluable in the project. We will also explore the possibilities of submitting fMRI data to one database, such as Neurogenerator.
Biostatistics: Development of relevant methods to independently and jointly analyse those data. These two components are separated, but having the methods development component mainly located at the database site will increase efficiency in project management, methods development and testing. This includes both setting up standard techniques that can run on very large amount of data and developing new analysis techniques that take advantage of the sample size.
The objectives of WP7 are as follows:
The objectives are as follows:
- Constructing of a centralized database receiving neuro imaging, genetic and behavioural data, checks data quality (neuroimaging),
- Setting up the database administration tools, the local (database site) and distant (partners sites) interrogation tools.
- Developing of statistical methods to analyse the database.
WP leader is Jean-Baptiste Poline who has strong expertise in functional images analyses. Jean-Baptiste Poline was also one of the first to analyse multi centric functional data and has co-authored SPM, a standard in the community. The laboratory UNAF-SHFJ-CEA at Orsay is the largest for neuro imaging data analysis in France. It is well recognised for anatomical (T1 and diffusion images) and functional (BOLD) imaging analyses. The laboratory has also strong expertise in the computer science aspect of neuroimage data analyses (see the BrainVisa project, www.brainvisa.info, and www.madic.org).
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